When you buy any new carb, it's your's to do whatever you want to do with it. A used one? You don't really know.
But,if your carb's jetted right, and is working as designed, you seldom EVER have to mess with it. If your Jetting is right for where you live, then it'll work fine anywhere else. The more air, and the denser, the more fuel it will pull through the systems, so you shouldn't have to mess with anything except the idle circuit tuning . . If you do, then you have something else wrong with your tuning combination!
But again, that's only what all my past mentors have had to say about a Carburetor . . In the last 4 years, now, all my experience has been with the SV-1, so I'm no Holley Expert!