No you can run a dome piston with NOS.. ( broad answer here)
...but of course as you know there is a-lot more to this story in building a proper Nos Motor other than just pistons...
if you need more info..let us know..there are guys on here that can tell you from the piston's,proper cam selection, fuel delivery, proper timing extraction etc........
thanks brian
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Bjuice..
"I'M YOUR HUCKLEBERRY ! "