it depends on how much you wanna spend! You could go with a Vortech blower, F2, Twins it doesnt matter. What gives you the best chances in your class (with wieght penelties)? You can make any one of those setups go lights out fast....just gotta figure where you wanna spend your money.
As for harder on parts, once you get to a certain hp point any setup is going to stress your parts bad! Go Big or go home!!!