Far as I know, you have to have the correct gaskets and "O" rings in your fuel delivery system, and of course, proper jetting . .
There's guys that come up here that's a lot smarter on Alky carbs than I am . . I have always worked with straight Methanol or Ethanol through an Enderle injector . . Dunno much about carbs, yet . . But I'm learning . .
It gets a bunch simpler when you use a Throttle Body Setup or something similar. You let the computer figure it all out . .