like gmc said its about controlling the detonation and a/f ratio.
if you gonna spray around 200 shot..place forged pistons in the engine and a middle of the road CAM that will still have some ok bottom end on motor passes and wide enough lobe seperation to reap the benefits when you spray it....remember you can't have the best of both worlds with sprayng and running strong on motor
make sure you have more than adequate fuel supply, and Knock a minimum of 2 degree's of timing out per 50hp of Nos used
also use Good Fuel when spraying..minimum 110 octane..112 ain't a bad thought either.
ohh yes if its race only..don't waste your time with 100 shot...your wasting your time and money...Hit it with 200 minimum or stay away from it.